Category: Technology

Regenerate, Rejuvenate and Reverse – Stem Cell Therapy and Heart Disease

The World Health Organization (WHO) has stated that cardiovascular disease is the leading cause of death worldwide. Many people that are living with damaged hearts find themselves easily fatigued and unable to perform simple everyday actions. This has warranted ongoing research into finding a cure for the condition. Recently, a study published in Nature has shown that stem cell technology may be used to reverse heart damage. Most patients that currently suffer from heart disease treat the condition with medication, but the stem cell therapy will enable a regrowth of healthy cells.

The study was conducted by a team of researchers from Shinshu University. The method they proposed would involve transplanting stem cells into the heart, encouraging it to repair itself. Stem cell transplants have already been used to treat leukemia, lymphoma, Parkinson’s Disease and Alzheimer’s successfully. The process recommended by Shinshu has already been tried on primates, with good results. Some of the hearts with the transplanted cells began to beat irregularly, but there were no adverse effects of this and scientists are confident that the procedure will work well for humans.

One of the possible problems with transplanting stem cells is the risk of them being rejected by the body, as the immune system tries to protect it. This can be prevented by ensuring that the protein from the donor cells matches the recipient’s. Our immune system uses these proteins to identify harmful foreign bodies. In addition, taking mild immunosuppressants will ensure the stem cells survival for at least 12 weeks. This gives the body an adequate amount of time to accept the stem cells, and the damaged cells in the heart to begin repairing themselves.

After many years of research, Mayo Clinic has also developed a procedure that has allowed the successful transplant of stem cells into patients with heart disease. Their process involves harvesting these cells directly from the patient’s bone marrow, and then changing them into cardiac cells in a laboratory. These are then injected into the patient’s heart, where they will stimulate the growth of healthy tissue.

To refine this process, the heart was first examined at a subcellular level. During this assessment, the team discovered that there were hundreds of proteins present in cardiac tissue. They then used computer technology to separate the proteins, and found that eight of these were necessary for healthy cells in the heart. This led Mayo Clinic’s team to correctly create stem cells which would not be rejected by the immune system, creating the possibility of a more energetic way of life for those living with heart disease.

Fighting HIV – Using the Cells it Affects

Methods to treat HIV (Human Immunodeficiency Virus) have improved greatly since the virus first began to affect humans, in the late 1980s. A few of those infected never developed full-blown AIDS, but for the majority, the inevitable result would have been wasting away due to an inability to fight diseases. Treatment for HIV has improved continuously, and the disease is no longer considered to be fatal once the affected person receives treatment. These treatments have at least two disadvantages, however: they would need to be continued for the duration of the individual’s lifetime and there are also uncomfortable side effects. Researchers are confident that there will eventually be a cure for HIV, and they continue to do tests that may take us closer to finding one.

Scientists from The University of Massachusetts Medical School have published an article in Nature, which states the possibility of decreasing the spread of HIV using cells which occur naturally in our bodies. Ironically, these are the same cells which the virus attacks. HIV breaks down the immune system by infecting and destroying CD4 positive ‘helper’ T-cells.

These white blood cells are vital to fighting off infection, which is why HIV is so efficient at wrecking havoc in the immune system. After affecting some of the cells, the virus uses these to travel through the body and infect other CD4s. T-cells transport these by settling in between lymph nodes, and others areas, that the free virus would be unable to reach.

The researchers found that there are proteins in the T-cells in our immune system which naturally fight HIV. SERINC5 and SERINC3, two host cell proteins, are able to stifle HIV-1 by greater than 100-fold. The HIV-1 genome has nine genes which can be replicated in the host cell, which then produce virions (the infectious part of the virus). They begin a cycle of infection by looking for new cells to infect. One of these, NEF (which is a key part in the development of AIDS) helps the process by blocking the SERINC proteins, so that they are unable to reach the cell’s surface. This means that they will no longer become a part of the newly formed virions. Developing a drug to restrict NEFs would allow the system to fight HIV, as the virions would then include SERINC3 and SERINC5 making them unable to infect new cells. This process could then be applied to other infectious viruses with NEF proteins.

The Cassini Probe – Exploring the Possibility of Life on Saturn

In 2004, the Cassini spacecraft began the first in-depth study of the planet Saturn. The vessel is equipped with 12 instruments, which have been designed to collect data about several areas of the planet: including its moons, rings, environment and magnetosphere. The knowledge that the spacecraft has uncovered is so extensive that the mission has been extended twice. The final mission, a seven year period called Cassini Solstice Mission, will end with ‘The Grand Finale.’ This event is scheduled to incorporate 22 deep dives between the planet’s clouds and innermost ring, ending with a massive plunge directly into its atmosphere.

Cassini has unveiled a significant amount of information about the planet’s system, it many moons and the rings which surround it. Its largest moon, Titan, has shown many features which scientists believe are similar to those that would have appeared on our planet, before life on Earth evolved. These include: lakes, rivers, dunes and possibly volcanoes. Another moon, Enceladus, has also yielded unexpected observations. This moon has a spray of icy particles that form a towering plume from its surface, which is three times its diameter. These geyser-like jets spew water vapor and ice particles into Saturn’s most expansive ring, the E ring, at an average of 800 miles per hour from an underground ocean beneath the moon’s icy crust. Measurements taken by the vessel, show the water body to be approximately 6 miles deep under an icy shell between 19 and 25 miles thick.

Coming as close as 15 miles to the moon, Cassini has unearthed that the fresh coating on it, and the icy particles fed into the E ring, originate from vents which are connected to a global subsurface saltwater ocean. The E ring is made mostly of ice droplets, but contains peculiar nanoparticles which Cassini detected. These can only be generated where liquid water and rock interact at temperatures greater than 90 degrees Celsius. This had led scientists to speculate that there may be hydrothermal vents beneath Enceladus’ icy shell, similar to those that can be found on Earth’s ocean floor. The information that Cassini has sent back to Earth, also revealed molecular hydrogen and carbon dioxide to be present. These factors are essential for methanogenesis, a process which sustains tiny life forms in dark underwater environments, to take place.

The plume venting from Enceladus’ south pole, the hydrocarbons within the plume, and a salty ocean with hydrothermal vents all point to a habitable surface and the possibility of locating life beyond Earth’s atmosphere. The three necessities for sustaining life: water, organic molecules, and an energy source have been found on Enceladus. This discovery is believed to be one of the most scientifically interesting finds about our Solar System to date and, as more information is collected from Cassini, there may be additional evidence that will help to prove the theory.

Chargeable Roads – Expanding the Use of Electronic Vehicles

Many countries are opting to use sustainable methods of public transport, such as electric vehicles, to create a safer, healthier environment for their citizens. There are disadvantages of their use, however, such as the large batteries that are needed for their operation and the need to plug them in at charging stations. To avoid these inconveniences, the Israeli government is collaborating with ElectRoad to install roads which will charge electric buses on their journey, starting with one of Tel Aviv’s current bus routes.

https://www.electroad.me/

ElectRoad is proposing to create a wireless system which will be economic enough to be adapted for cities worldwide. The company has no doubts that their ‘inductive charging’ technology is completely cost effective and allows buses to carry light, inexpensive batteries instead of the heavy ones currently equipping them. The buses will also be charged while on the go, eliminating the need for stationary periods to recharge. Once installed the infrastructure will be able to charge any vehicle which has a compatible battery.

The company demonstrated the technology at their headquarters in Caesarea, winning a $12,000 grant from Israel’s Ministry of Transport and Road Safety to help fund the installation of the new road. The route will be approximately 1/2 a mile in length and is expected to open in 2018. If it proves to be a worthwhile investment, the Israeli government plans to expand on the use of this technology. Other countries, including South Korea, have already installed several wireless bus routes. ElectRoad believes that their option is more affordable on a large scale, however, because of the cheaper transformers which are required and the shorter, more efficient installation process.

Induction charging is a process which has been used to create power sources since the 1890s and involves the creation of energy from the interaction of two electromagnetic fields. This will be the first time the technology will be applied to an item as large as a bus. Plates of copper will be embedded into the roads, which will be supplied with power from inverters placed along the sides. Copper plates will also be installed on the underside of the buses, allowing the two fields to interact as the buses drive over. The technology can be installed into existing roads with minor disruptions, and the buses will be able to travel off the charging road for about three miles. Each vehicle will be required to have a small battery onboard to facilitate acceleration, as well as travel outside the charging zone.

There are several disadvantages which have been raised about the installation of these roads, however, which ElectRoad are confident they will be able to overcome. This includes the fact that the buses might stray from the main strip or become misaligned. The batteries for electric vehicles are also becoming cheaper, lighter and more efficient. The company acknowledges that the prices of batteries have fallen significantly but also claim that their technology is to be used for citywide infrastructure on larger scales, and they remain optimistic about its expansion.

FCX-001 – Bell Helicopter’s Futuristic Flying Machine

Bell’s Helicopter unveiled their latest flying vehicle in March 2017 at the Heli-Expo in Dallas, Texas. Known as the FCX-001, it includes the latest advancements in flight technology. The advanced airframe design is constructed from sustainable materials, which will provide increased structural performance and can be adapted to suit different clients. They will also provide enhanced visibility, as well as a larger area for those that occupy the helicopter. The vehicle’s frame is its frontline for energy management where external energy, or unused system energy, is harvested, stored and distributed.

The FCX-001 is set to run on hybrid power, which will combine thermal engine cores with electric distribution and motors to drive the anti-torque system. This will allow for better control, simpler operations and less maintenance. In addition, the system’s flight control is operated via three separate and independent computers. During a journey, the system evaluates and calculates the optimal method to process the digital orders that the pilot has provided. This ensures that the aircraft will not be compromised during flight, and is supported by extra redundancy. The anti-torque system within the aircraft, is also designed to improve safety conditions, and monitor noise levels and performance parameters. It is embedded in the tail boom, and uses thrust vectoring control capability.

Image: Bell Helicopter

The company has been researching ways of applying morphing technology to different areas of flight, for an extended period. In the FCX-001, the morphing rotor blades have been designed so that the aircraft will be able to optimise its performance under different flight conditions. Individual morphing technologies were applied such as blades, inlets and aerodynamic surfaces, through advanced actuation, materials or a combination of both. The helicopter also has futuristic landing gear on board, which has been designed using non-traditional geometric structures. This will combine with its advanced building material to facilitate an increased function. The use of actuation was also applied to improve the vehicle’s manoeuvring capabilities, as well as absorb the landing energy for improved safety and comfort in ground operations.

Another area that the company focused on when designing the FCX-001 was the gradual transition to autonomous vehicles that is currently taking place. The cockpit is equipped with a single pilot seat, and the Multi Functional Display removed to enhance the pilot’s visibility during flights. The aircraft will be controlled using augmented reality and an artificial intelligence computer system. The pilot will be able to control the vehicle’s safety and the direction of the mission, while the computer operates as a co-pilot. This is a necessary step in moving over to include a fully autonomous pilot system in these aircrafts. As well as the pilot’s area, the cabin is enhanced with a flooring system which allows for seating changes to accommodate various passengers or cargo. It also contains fully customisable LED lighting and pop-down air ventilation systems, which will help to increase passengers’ comfort.

Cryogenics – Re-establishing Life After Death

The human body is capable of amazing things, such as healing broken bones and regenerating cells. Regardless of our regenerative abilities we are still unable to avoid death, and there are many people who would like to prolong their lives. For this reason they are preserving their body in liquid nitrogen, in a process called cryogenics, with the hope that science will soon be advanced enough to give them new life. Even though cryogenic freezing is only possible after a person has been declared legally dead, people with diseases which cause their death are also opting to be frozen, believing that they can be resurrected after a cure has been found.

The process of freezing the body begins as soon as possible after death to minimize potential brain damage. It is first cooled in an ice bath to gradually reduce its temperature, and in some cases CPR may be administered to prevent the death of brain cells. The blood is then drained from the person’s system and replaced with an anti-freeze fluid, to prevent harmful crystals from forming within the blood. After this initial process, it is packed in ice and transferred to a holding facility in either the United States or Russia.

Upon arrival, the body is put in an arctic freezing bag to be cooled by nitrogen gas to -196 C over a period of two days. Each one is then transferred to a storage facility, known as a ’patient care bay,’ where it remains suspended in liquid nitrogen until it will be time to resurrect it. The process can also be performed by removing the head and freezing it without the body. This is known as neuro-cryopreservation and is done in the expectation that a new body can be cloned, to attach the head to, when the technology becomes available.

Acclaimed neuroscientist, Dr. Sergio Canavero, has recently announced that the world’s first human head transplant will be attempted within the next 10 months. The operation will take place on a Chinese citizen, in Harbin, China, who will be the recipient of a donor body. Its success will also lead to even greater advances, as the team will then attempt to reawaken the first frozen head. Canavero will remove the brain from a cryogenically frozen head and transplant it in a donor body, resulting in the first technologically assisted human resurrection.

There have been no documented experiments to date, in which a mammalian brain has been re-awakened after being frozen in liquid nitrogen. This means that scientists are unsure of the possible complications that may occur. Irreversible damage may have occurred during the freezing process, and upon awakening the individual may display decreased mental facilities or great emotional trauma. In addition to possible complications, the success of the reawakening will answer other questions such as what really happens after death and how well the process of cryogenics really works.